Where in the cell is TMPRSS2 localized?

In human prostate cancers, TMPRSS2 protein is localized on the apical membrane of secretory epithelia and in the lumen of the glands.

What cells express TMPRSS2?

Regarding lung (a primary site of infection) it was recently found that both the ACE2 and TMPRSS2 genes are primarily expressed in bronchial transient secretory cells [22]; it was also found that SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells [23].

What is TMPRSS2 ERG?

TMPRSS2 is a prostate-specific and androgen-response gene that encodes a protein belonging to the serine protease family, which functions in prostate carcinogenesis and relies on gene fusion with ETS transcription factors, such as ERG and ETV1 (8).

What is TMPRSS2 inhibitor?

TMPRSS2 has an extracellular protease domain capable of cleaving a spike protein domain to initiate membrane fusion. Considering the vital role played by TMPRSS2 in the viral life cycle, this protease has received great attention to be used as a potential target to inhibit viral entry into host cells.

What is the role of TMPRSS2 in SARS-CoV-2 replication?

SARS-CoV-2 engages ACE2 as the entry receptor and uses TMPRSS2 for spike protein priming. Serine protease inhibitors, like camostat mesylate, can inhibit TMPRSS2 and partially block SARS-CoV-2 spike protein-driven entry.

What is ERG oncogene?

ERG (ETS-related gene) is an oncogene. ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator.

What does ERG positive mean?

Positive staining – disease. Highly sensitive and specific marker for benign and malignant vascular tumors (Am J Surg Pathol 2011;35:432)

How does Camostat mesylate inhibit TMPRSS2?

Background. Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2.

How do you measure erg?

erg, unit of energy or work in the centimetre-gram-second system of physical units used in physics; to lift a pound weight one foot requires 1.356 × 107 ergs. It equals the work done by a force of one dyne acting through a distance of one centimetre and is equal to 10-7 joule, the standard unit of work or energy.

How big is an erg?

An erg is the amount of work done by a force of one dyne exerted for a distance of one centimetre. In the CGS base units, it is equal to one gram centimetre-squared per second-squared (g⋅cm2/s2). It is thus equal to 10−7 joules or 100 nanojoules (nJ) in SI units.

How big is an ERG?

What is ERG stand for?

It’s an acronym you should know. ERG stands for employee resource group. Other lesser used terms include affinity groups or business networking groups. Current groups offer much more than mere professional networking opportunities. ERGs can be found in 90% of Fortune 500 companies.

How long is a rowing erg?

The Concept2 Indoor Rower measures 8′ long by 24” maximum width. An area of 9′ by 4′ is required for operation of the machine.

How do you calculate erg?

An erg is the amount of work done by a force of one dyne exerted for a distance of one centimetre. In the CGS base units, it is equal to one gram centimetre-squared per second-squared (g⋅cm2/s2). It is thus equal to 10−7 joules or 100 nanojoules (nJ) in SI units….

erg
British Gravitational System	7.375621×10−8 ft⋅lbf

Why are ERGs so important?

ERGs support learning and development by offering formal and informal leadership opportunities and creating visibility for employees who are active. ERGs also provide a resource for leadership and decision-makers regarding staff/community issues, needs and policies.