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Is there a difference between carboplatin and cisplatin?

Is there a difference between carboplatin and cisplatin?

Cisplatin and carboplatin have different toxicity profiles; cisplatin is associated with a higher rate of nausea, vomiting, nephrotoxicity, ototoxicity, while carboplatin has a higher risk of myelosupresssion and neurotoxicity6.

Is carboplatin stronger than cisplatin?

Conclusions: For some tumors, cisplatin appears to be superior to carboplatin in terms of therapeutic effectiveness (germ cell tumors, bladder cancer, head and neck cancer), while for others, effectiveness is comparable (lung cancer, ovarian cancer).

What are the advantages of carboplatin over cisplatin?

Meta-analyses of palliative chemotherapy indicate consistent survival advantages with cisplatin-based therapy over carboplatin; however, the relative advantage is small. Cisplatin carries a higher toxicity profile, including nausea, vomiting, neuropathy, renal insufficiency, and alopecia in comparison to carboplatin.

Is cisplatin used for lung cancer?

Cisplatin, a platinum-based chemotherapeutic drug, has been used for over 30 years in a wide variety of cancers with varying degrees of success. In particular, cisplatin has been used to treat late stage non-small cell lung cancer (NSCLC) as the standard of care.

Is carboplatin effective on its own?

Any effect carboplatin has is usually mild and will get better by itself.

Does chemo work on stage 4 lung cancer?

As with stage 4 NSCLC, treatment would likely focus on blocking the cancer’s growth, relieving symptoms and extending the patient’s life. Chemotherapy and immunotherapy, or a combination of both, are typically the first line of treatment at this stage.

How long does chemo prolong life in lung cancer?

Chemotherapy (chemo) may prolong life in some lung cancer patients. According to a study reported in the Journal of the American Medical Association that looked at the role of chemotherapy at the end of life, chemo for some patients with a specific type of lung cancer prolonged their lives by two to three months.

How do you reduce the side effects of carboplatin?

Use an electric razor and a soft toothbrush to minimize bleeding. Avoid contact sports or activities that could cause injury. To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals. Avoid sun exposure.

Which is better for SCLC cisplatin or carboplatin?

Our meta-analysis of individual patient data suggests no differences in efficacy between cisplatin and carboplatin in the first-line treatment of SCLC, but there are differences in the toxicity profile.

How is carboplatin used in the treatment of lung cancer?

Carboplatin- or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer: the COCIS meta-analysis of individual patient data J Clin Oncol. 2012 May 10;30(14):1692-8.doi: 10.1200/JCO

Is the platinum molecule the same as cisplatin?

The platinum (II) molecules exist in a planar structure in with the two amine groups and the two reactive “leaving” chloride (cisplatin) and cyclobutane-decarboxylate (carboplatin) groups existing in the same configuration ( Fig. 1) ( Reed, 1998 ).

Which is better cisplatin or taxotere for NSCLC?

Having one doublet do significantly better than any other is pretty rare, so that’s why some people would perhaps consider the cisplatin/taxotere doublet to be among the most active combinations for NSCLC, albeit by a small margin.