Is vincristine soluble in water?

Vincristine Sulfate, USP is a white to off–white powder. It is soluble in methanol, freely soluble in water, but only slightly soluble in 95% ethanol. In 98% ethanol, Vincristine Sulfate, USP has an ultraviolet spectrum with maxima at 221 nm (∈+47,100).

How do you reconstitute vincristine?

It is recommended to infuse vincristine sulfate over 5 to 10 minutes after dilution in a 50 ml infusion bag with Sodium Chloride 9 mg/ml (0.9%) Solution for Injection. After administration the vein must be flushed through thoroughly.

How do you inject vincristine?

The solution may be injected either directly into a vein or into the tubing of a running intravenous infusion (see Drug Interactions below). Injection of Vincristine Sulfate Injection, USP (vincristine sulfate) should be accomplished within 1 minute. The drug is administered intravenously at weekly intervals.

Is vincristine a Vesicant?

Vincristine is given through a vein by intravenous injection (IV push) or infusion (IV). There is no pill form. Vincristine is a vesicant. A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein.

What is vincristine chemical formula?

C46H56N4O10
Vincristine/Formula

Vincristine is a vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.

What are the side effects of vincristine?

Vincristine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea.
• vomiting.
• sores in the mouth and throat.
• loss of appetite or weight.
• stomach pain.
• diarrhea.
• headache.
• hair loss.

Why is vincristine capped at 2 mg?

Background: Most current lymphoma protocols limit vincristine dose to 2 mg per single dose. Because a lower dose of vincristine may be associated with poorer outcome, there is some rationale to increase the dose of vincristine.

Why does vincristine have side effects?

If vincristine leaks out of the vein into the surrounding area, it may cause serious skin and tissue damage. Tell your health care professional right away if you experience pain, irritation, redness, or swelling at the injection site. Prompt treatment of the leakage will help reduce discomfort and possible skin damage.

What are the long term side effects of vincristine?

With continued treatment, neuritic pain and later, motor difficulties may occur. Loss of deep-tendon reflexes, foot drop, wrist drop, ataxia, and paralysis have been reported with continued administration.

How long is vincristine sulfate stable in blood?

Vincristine Sulfate Injection, USP when diluted with 0.9% Sodium Chloride Injection in concentrations from 0.0015 mg/mL to 0.08 mg/mL is stable for up to 24 hours when protected from light or 8 hours under normal light at 25°C.

What is the structural formula for vincristine sulfate?

The structural formula is as follows: Vincristine Sulfate, USP is a white to off–white powder. It is soluble in methanol, freely soluble in water, but only slightly soluble in 95% ethanol. In 98% ethanol, Vincristine Sulfate, USP has an ultraviolet spectrum with maxima at 221 nm (∈+47,100).

What is the dose of vincristine sulfate for adults?

The usual dose of Vincristine Sulfate Injection, USP for adults is 1.4 mg/m2. A 50% reduction in the dose of Vincristine Sulfate Injection, USP is recommended for patients having a direct serum bilirubin value above 3 mg/100 mL.

What is the melting point of vincristine 2 +?

It is a conjugate base of a vincristine (2+). It derives from a hydride of a vincaleukoblastine. Vincristine appears as a white crystalline solid. Melting point 218°C. Used as an antineoplastic.