Miscellaneous

What are extranodal lymphomas?

What are extranodal lymphomas?

Extranodal lymphoma, by definition, involves sites other than lymph nodes, spleen, thymus and the pharyngeal lymphatic ring. Involvement of the spleen in HD is considered as nodal disease but in the case of non-Hodgkin lymphoma (NHL) the spleen is regarded as an extranodal site.

What is extranodal DLBCL?

Non-Hodgkin lymphomas commonly show extranodal involvement (25-30%) but primary diffuse large B-cell lymphomas (DLBCL) with extranodal localization represent clinically and molecularly distinct entities.

What is extranodal presentation?

An extranodal presentation of HL is unusual and the most common sites of presentation for extranodal extension are the spleen, liver, lungs, bones and marrow. However, such instances are seldom observed in the clinic. The bones frequently involved are the vertebrae, pelvis, ribs and femur (4,8,22,27,28).

Can you survive NK T-cell lymphoma?

In the retrospective International Peripheral T-cell Lymphoma Project, the median overall survival among patients with ENKL was 3 years for localized and 8 months for advanced disease. Despite the short median overall survival, with most current treatment approaches, a significant number of patients are cured.

Is extranodal lymphoma treatable?

A combined treatment with chemotherapy and RT is considered a valid therapeutic approach in patients with localized NHL, either nodal or extranodal, in most anatomic sites, including Waldeyer’s ring (100-102). However, the combinatory treatment is often associated with relevant acute and chronic toxicity (99,103).

What causes extranodal lymphoma?

Extranodal NK/T-cell lymphoma, nasal type, is strongly linked to infection with a virus called Epstein-Barr virus (EBV). EBV is a very common virus that can cause glandular fever. After you’ve been infected with it, EBV stays in your body but it is normally kept under control by your immune system.

Is DLBCL a rare disease?

This is a fast-growing lymphoma, but it usually responds well to treatment. There are several other subtypes of DLBCL, but these are rare.

What does Stage 2 lymphoma mean?

Stage 2 means there is lymphoma in two or more groups of lymph nodes. These can be anywhere in the body, but to be diagnosed with stage 2 lymphoma, they must all be on the same side of the diaphragm.

What is the survival rate of NK T-cell lymphoma?