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What is an autoinflammatory syndrome?

What is an autoinflammatory syndrome?

Autoinflammatory syndromes (AIS) are disorders of innate immunity which present with recurrent episodes of fever and skin lesions, such as urticaria, pustules, maculopapular rash, oral ulcers, generalized pustular psoriasis, or pyoderma gangrenosum-like lesions.

How do you treat auto inflammatory disease?

The therapy with the most important and widespread effect on autoinflammatory disorders is colchicine, a medication extracted from the meadow saffron and used since the first century for rheumatologic diseases, such as gout.

What causes autoinflammatory syndrome?

Autoinflammatory diseases are caused by abnormal activation of the innate immune system, leading to recurrent episodes of fever and inflammation that can damage vital organs. Our researchers are revealing how the innate immune system goes awry in autoinflammatory disease.

Is Yao syndrome real?

Yao syndrome (YAOS) (formerly called NOD2-associated autoinflammatory disease) is an autoinflammatory syndrome involving episodes of fever and abnormal inflammation affecting many parts of the body, particularly the skin, joints, and gastrointestinal system.

How common is autoinflammatory disease?

Cryopyrinopathies or cryopyrin-associated periodic syndromes (CAPS): a group of three rare autoinflammatory diseases that includes familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous articular syndrome (CINCA) with an estimated prevalence of 1 3 cases …

How is an autoinflammatory disease diagnosed?

A diagnosis of an autoinflammatory disease can be made with a physical examination, a review of family medical history, bloodwork, and genetic testing.

How is Yao syndrome treated?

As a systemic disease, Yao syndrome uncommonly affects the solid internal organs, but it can be complicated with chronic pain syndrome and even disability. Glucocorticoids or sulfasalazine may be considered as the first-line treatment option, and interleukin (IL)-1/IL-6 inhibitors may be tried for refractory cases.

How rare is Yao syndrome?

Yao syndrome has an estimated prevalence of 1 in 10,000 to 1 in 100,000 people worldwide. Studies suggest that it is among the most common systemic (affecting the whole body) autoinflammatory diseases in adults. For unknown reasons, Yao syndrome appears to affect women more frequently than men.

Which autoimmune diseases cause inflammation?

Rheumatoid arthritis (RA) is a chronic autoimmune disease that typically causes inflammation of the joints and the encompassing tissue.

What diseases cause inflammation?

However, chronic inflammation can eventually cause several diseases and conditions, including some cancers, rheumatoid arthritis, atherosclerosis, periodontitis, and hay fever. Inflammation needs to be well regulated.

What are some rare autoimmune diseases?

Dermatomyositis is a rare autoimmune disease. Dermatomyositis is a rare autoimmune disease, occurring in only 5-10 people per million, which is caused by the body’s immune system attacking its own skin and muscles.

Is RSD an autoimmune disease?

Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is an autoimmune disorder caused by damage to the autonomic nervous system. Usually starting in a limb, it manifests as extreme pain, swelling, limited range of motion, and changes to the skin and bones.