What is SAPHO syndrome?

Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized by synovitis, osteitis, hyperostosis, and enthesitis, typically with pain, swelling, and tenderness in affected areas.

How common is SAPHO?

To date, SAPHO syndrome in considered a rare disease, however its prevalence is probably underestimated. Its prevalence is considered not more than 1/10 000. SAPHO syndrome can be seen in all ages, but it is more frequent in children and young to middle-aged adults with a female predominance.

What causes SAPHO?

SAPHO is an acronym for the combination of synovitis, acne, pustulosis, hyperostosis, and osteitis. Some researchers feel that the SAPHO syndrome is related to the group of arthritis conditions which typically affect the spine, called the spondyloarthropathies.

Is there a cure for SAPHO syndrome?

There is no specific treatment plan for SAPHO syndrome . It can be a chronic condition but sometimes eventually heals on its own. Joint pain may be managed with nonsteroidal anti-inflammatory drugs and prescription vitamin A is used to treat the acne.

Is SAPHO syndrome painful?

In these cases, the condition is long lasting, but the symptoms do not cause any pain. In most people , symptoms involving the bones and joints will not worsen. In some individuals, SAPHO syndrome will heal by itself over time.

Is SAPHO syndrome a disability?

If you or your dependent(s) are diagnosed with Sapho Syndrome and experience any of these symptoms, you may be eligible for disability benefits from the U.S. Social Security Administration.

Is SAPHO syndrome genetic?

The etiology is unknown. SAPHO syndrome seems to have a multifactorial origin with genetic, environmental, immunologic, and infectious components. Slow-growing bacteria, such as Propionibacterium acnes, could act as a triggering factor.

Is SAPHO genetic?

The pathogenesis of SAPHO is probably multifactorial and it involves a combination of genetic, infectious, and immunological components.

Does RA cause acne?

RA is a type of autoimmune, inflammatory arthritis. This means that if you have RA, you have higher levels of inflammation in your body, particularly in your joints. Though acne may not be related to RA, it’s also an inflammatory condition.

Is SAPHO syndrome an autoimmune disease?

Background/Purpose: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoimmune disease with heterogeneous presentation and severe disease burden.

What autoimmune diseases causes acne?

RA and certain types of acne are inflammatory conditions. RA is a type of autoimmune, inflammatory arthritis. This means that if you have RA, you have higher levels of inflammation in your body, particularly in your joints. Though acne may not be related to RA, it’s also an inflammatory condition.