What is the pathogenesis of RA?


What is the pathogenesis of RA?

Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and bone.

What are the complications of RA?


  • Osteoporosis.
  • Rheumatoid nodules.
  • Dry eyes and mouth.
  • Infections.
  • Abnormal body composition.
  • Carpal tunnel syndrome.
  • Heart problems.
  • Lung disease.

What is the etiological agent for rheumatoid arthritis?

Human parvovirus B19 as a causative agent for rheumatoid arthritis.

What is the mechanism of action of rheumatoid arthritis?

The second possible pathway for bone loss in RA involves two mechanisms for autoimmunity that act as a trigger for structural bone damage. The first mechanism pertains to the formation of immune complex and Fc-receptor-mediated osteoclast differentiation.

Is rheumatoid factor pathogenic?

Rheumatoid factors (RF) participate in the pathogenesis of rheumatoid arthritis by formation of immune complexes. IgM-RF form complement activating immune complexes with IgG-containing antigen-antibody complexes. IgG-RF form unique immune complexes without the presence of separate antigen molecules.

How do you classify rheumatoid arthritis?

A patient was classified as having RA if at least four of these seven criteria were satisfied; four of the criteria must have been present for at least six weeks: morning stiffness, arthritis of three or more joint areas, arthritis of the hands, and symmetric arthritis.

What are the main features of rheumatoid arthritis RA )?

Signs and symptoms of RA include:

  • Pain or aching in more than one joint.
  • Stiffness in more than one joint.
  • Tenderness and swelling in more than one joint.
  • The same symptoms on both sides of the body (such as in both hands or both knees)
  • Weight loss.
  • Fever.
  • Fatigue or tiredness.
  • Weakness.

What is rheumatoid factor NCBI?

Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects.

What is the typical joint involvement with rheumatoid arthritis?

The joints involved most frequently are the proximal interphalangeal (PIP) and metacarpophalangeal (MCP) joints of the hands, the wrists, and small joints of the feet including the metatarsophalangeal (MTP) joints. The shoulders, elbows, knees, and ankles are also affected in many patients.