What is the role of lecithin cholesterol acyltransferase?


What is the role of lecithin cholesterol acyltransferase?

The LCAT gene provides instructions for making an enzyme called lecithin-cholesterol acyltransferase (LCAT). This enzyme plays a role in removing cholesterol from the blood and tissues.

Which apolipoprotein activates lecithin cholesterol acyltransferase?

Human plasma apoproteins (apo) A-I and A-IV both activate the enzyme lecithin:cholesterol acyltransferase (EC 2.3. 1.43).

What is esterification of cholesterol?

To more efficiently transport both dietary and synthesized cholesterol, it is converted to cholesteryl esters. Free cholesterol can be taken up by lipoproteins, but is confined to the outer surface of the particle.

How does lecithin affect cholesterol?

Lecithin is capable of reducing LDL-cholesterol. It also promotes the HDL-cholesterol synthesis [27]. In addition to be used to help reduce cholesterol and triglycerides and protect the liver in the prevention of kidney stone formation, it is used as a tonic for the nervous system and brain activities.

Where is lecithin cholesterol acyltransferase produced?

LCAT is approximately a 67-kDa sized secretory protein that is primarily produced in the liver but is also synthesized in the central nervous system [1]. It associates with lipoproteins, with the majority bound to HDL and to a lesser degree to low-density lipoproteins (LDL).

What are the difference between free and esterified cholesterol?

Cholesterol is present as unesterified (free) and esterified portions in the body fluids (1). Free cholesterol is biologically active and has cytotoxic effects whereas cholesteryl ester (CE) is protective form for storage in the cells and transporting in plasma (23).

What is LCAT deficiency?

LCAT (lecithin-cholesterol acyltransferase) deficiency is a rare lipoprotein metabolism disorder characterized clinically by corneal opacities, and sometimes renal failure and hemolytic anemia, and biochemically by severely reduced HDL cholesterol.

Is lecithin good to reduce cholesterol?

How much lecithin should I take to lower cholesterol?

Cholesterol reduction Lecithin supplements have also shown promise in lowering cholesterol. In a 2008 study, participants took 500 milligrams (mg) of soy lecithin a day. After 2 months, the average total cholesterol was reduced by 42 percent, and LDL cholesterol was reduced by 56.15 percent.

Which lipoprotein has highest cholesterol content?

LDL (low-density lipoprotein), sometimes called “bad” cholesterol, makes up most of your body’s cholesterol. High levels of LDL cholesterol raise your risk for heart disease and stroke.