Is insulin resistance PCOS reversible?

A well-formulated ketogenic diet (WFKD) has been shown to reverse insulin resistance, reduce inflammation, as well as facilitate weight loss (10, 11). Therefore, women may be able to use a WFKD to ameliorate some of the powerful signals that are contributing to PCOS without the side effects of pharmaceutical treatment.

Is PCOS related to insulin resistance?

But it’s a lot more than that. This lifelong health condition continues far beyond the child-bearing years. Women with PCOS are often insulin resistant; their bodies can make insulin but can’t use it effectively, increasing their risk for type 2 diabetes.

Does hyperandrogenism cause insulin resistance?

Undertreatment causes hyperandrogenism, which is associated with insulin resistance, whereas overtreatment can induce increased insulin resistance due to glucocorticoid excess [61]. Additionally, obesity, which is commonly observed in CAH, may also exaggerate insulin signaling impairment.

How can I reduce my insulin resistance with PCOS?

Diet and exercise are the most fundamental ways for patients to manage insulin levels and control PCOS symptoms. Encourage them to engage in at least moderate exercise for 30 minutes a day to regulate blood glucose levels, even if all they can fit in is a walk at lunch. Also provide general guidance for healthy eating.

Why do androgens cause insulin resistance?

Since androgen receptors are also expressed in pancreatic and liver cells, high levels of testosterone can result in hyperinsulinemia. Moreover, Fetuin-A is a natural inhibitor of tyrosine kinase, and its overexpression in the liver leads to insulin resistance.

What should I eat for PCOS with insulin resistance?

The Optimal Diet and Exercise Regimen for Insulin-Resistant PCOS

• Eat organic when possible.
• Eat mostly plants, especially the cruciferous family of vegetables.
• Consume high-quality animal protein.
• Healthy fats.
• Eliminate processed and refined carbohydrates and replace them with slow-burning carbohydrates.

How does insulin resistance cause hyperandrogenism in PCOS?

It is thus possible that a single defect produces both the insulin resistance and the hyperandrogenism in some PCOS women (Fig. 19). Recent studies strongly suggest that insulin is acting through its own receptor (rather than the IGF-I receptor) in PCOS to augment not only ovarian and adrenal steroidogenesis but also pituitary LH release.

How does hyperandrogenism affect women with polycystic ovary syndrome?

As hyperandrogenism remains the main feature of PCOS, because up to 70–80% of PCOS women exhibit clinical manifestations of hyperandrogenism [9], it is thus becoming of great importance to understand the mechanisms by which insulin resistance or insulin actions may produce hyperandrogenemia in PCOS women.

How does insulin work in polycystic ovary syndrome?

Recent studies strongly suggest that insulin is acting through its own receptor (rather than the IGF-I receptor) in PCOS to augment not only ovarian and adrenal steroidogenesis but also pituitary LH release. Indeed, the defect in insulin action appears to be selective, affecting glucose metabolism but not cell growth.

How does serine phosphorylation affect insulin resistance in PCOS?

Serine phosphorylation appears to modulate the activity of the key regulatory enzyme of androgen biosynthesis, P450c17. It is thus possible that a single defect produces both the insulin resistance and the hyperandrogenism in some PCOS women (Fig. 19).