What did polly Matzinger discover?

What did polly Matzinger discover?

the immune system
Polly Celine Eveline Matzinger (born July 21, 1947, in La Seyne, France) is an immunologist who proposed the danger model theory of how the immune system works. In 2002, Discover magazine recognized Matzinger as one of the 50 most important women in science.

How old is Polly Matzinger?

74 years (July 21, 1947)
Polly Matzinger/Age

When was polly Matzinger born?

July 21, 1947 (age 74 years)
Polly Matzinger/Date of birth
In 2002, Discover magazine included Matzinger in its list of “The 50 most important women in science”, for her pioneering research into the workings of the human immune system. Matzinger was born on 21 July 1947 in La Seyne, southeastern France.

What is the danger theory?

The “danger theory” of Polly Matzinger posed in 1994 (Matzinger, 1994) principally holds that the immune system is far less concerned with “foreign” (microorganisms, cells, and molecules) than with signals that cause dangerous damage, and, furthermore, that antigen-presenting cells respond to danger signals—most …

What is the basic concept of immunology?

Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through various lines of defence. If the immune system is not functioning as it should, it can result in disease, such as autoimmunity, allergy and cancer.

What is immunological theory?

The immunological theory of aging asserts that the process of human aging is a mild and generalized form of a prolonged autoimmune phenomenon. In other words, aging—which involves a highly complex series of processes—is suspected to be largely controlled by the immune system.

What is the main aim of danger theory?

An outstanding feature of the danger theory concerns its proponents’ aim to determine an adequate criterion of immunogenicity, that is, a clear and testable answer to what triggers an immune response.

What are DAMPs in immunology?

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host’s defense, they promote pathological inflammatory responses.

Why would you be referred to immunology?

You may see an immunologist if you have food or seasonal allergies, hay fever, eczema or an autoimmune disease. When your immune system doesn’t work as well as it should, your body doesn’t have enough defenses against infection.

What is the importance of immunologic theory?

What is the stress theory of aging?

The oxidative stress theory of aging postulates that age-associated reductions in physiologic functions are caused by a slow steady accumulation of oxidative damage to macromolecules, which increases with age and which is associated with life expectancy of organisms.

How did Polly Matzinger come up with her theory?

In other words, her theory is that our immune systems are activated when our cells signal “we are being harmed, there is danger.” Polly Celine Eveline Matzinger was born on July 21, 1947 in La Seyne, close to the French Mediterranean city of Toulon.

Where is Polly Matzinger in the danger model?

The Danger Model: Update to immune system theory. Polly Matzinger stands alone on the main stage at the Back to Basic conference. An on-screen graphic identifies her as Chief, T-Cell Tolerance and Memory Section Laboratory of Immunogenetics. As she speaks, she draws on an overhead projector.

What did Seong Sy and Polly Matzinger do?

Seong SY, Matzinger P. Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat Rev Immunol. 2004 Jun;4 (6):469-78.