What do dipeptidyl peptidase 4 inhibitors do?
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What do dipeptidyl peptidase 4 inhibitors do?
DPP-4 inhibitors work by blocking the action of DPP-4, an enzyme which destroys the hormone incretin. Incretins help the body produce more insulin only when it is needed and reduce the amount of glucose being produced by the liver when it is not needed.
Which of the following drug is an inhibitor of dipeptidyl peptidase 4 enzyme?
List of Dipeptidyl peptidase 4 inhibitors:
| Drug Name | Avg. Rating | Reviews |
|---|---|---|
| Januvia (Pro) Generic name: sitagliptin | 5.2 | 112 reviews |
| Tradjenta (Pro) Generic name: linagliptin | 3.0 | 56 reviews |
| Onglyza (Pro) Generic name: saxagliptin | 5.9 | 15 reviews |
| Nesina (Pro) Generic name: alogliptin | 3.0 | 4 reviews |
How does a DPP-4 inhibitor work?
DPP-4 inhibitors work by blocking the action of an enzyme called DPP-4, which destroys the hormone incretin. Incretins are a group of hormones that are released throughout the day and increase at mealtimes.
Are dipeptidyl peptidase 4 inhibitors weight neutral?
Dipeptidyl peptidase (DPP)-4 inhibitors are generally weight-neutral, although modest weight loss has been observed with the DPP-4 inhibitor, vildagliptin, in patients with relatively low baseline glycemia. The weight neutrality of vildagliptin likely results in part from its intrinsically low risk for hypoglycemia.
What are the side effects of DPP-4 inhibitors?
Adverse effects of DPP-4 inhibitors include:
- gastrointestinal problems – including nausea, diarrhoea and stomach pain.
- flu-like symptoms – headache, runny nose, sore throat.
- skin reactions – painful skin followed by a red or purple rash.
Which is the best DPP-4 inhibitor?
Sitagliptin is ‘Safest’ DPP-4 Inhibitor for Type 2 Diabetes.