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What does the sevenless gene do?


What does the sevenless gene do?

Sevenless (sev) is a gene in Drosophila melanogaster that encodes a receptor tyrosine kinase protein essential to the development of R7 cells in the Drosophila embryonic eye. The R7 photo receptor, located in each of several ommatidium in the fly’s compound eye, is used to detect ultraviolet light.

What is bride of sevenless?

Description. During development of the Drosophila retina, the bride of sevenless (boss) gene is required in photoreceptor neuron R8 for the development of photoreceptor neuron R7, suggesting that boss encodes or regulates an R7-specific inductive cue. .

What are R7 cells?

The R7 photoreceptor, a unique cell type within the Drosophila ommatidium, was initially proposed to be specified by two distinct signals from neighboring cells, one from the R8 photoreceptor and another from the R1/6 photoreceptor pair.

What type of Signalling is Sevenless?

Sevenless (Sev) is a Receptor Tyrosine Kinase (RTK) that is required for the specification of the Drosophila R7 photoreceptor. This chimerical receptor acts indistinguishably from Sev itself; a result that is entirely consistent with the two RTKs sharing identical transduction abilities.

What type of signaling is Sevenless signaling?

Sevenless is a membrane-spanning receptor with an intracellular tyrosine kinase domain that signals in a way that closely resembles the signaling by hormone receptors such as the insulin receptor tyrosine kinase.

What transcription factors mark R8 photoreceptors in Drosophila?

factor Atonal
Within each cluster, the combined activities of Hedgehog signaling and Notch-mediated lateral inhibition induce and refine the expression of the transcription factor Atonal, which specifies the founding R8 photoreceptor of each ommatidium.


Proper regulation of receptor tyrosine kinase (RTK)-Ras-mitogen-activated protein kinase (MAPK) signaling pathways is critical for normal development and the prevention of cancer. SOS is a dual-function guanine nucleotide exchange factor (GEF) that catalyzes exchange on Ras and Rac.

What does SOS do to Ras?

In common with other GEFs, SOS activates Ras by causing dissociation of the otherwise tightly bound nucleotide, thereby facilitating the binding of guanosine triphosphate (GTP) (Bos et al.

What is Sevenless Signalling?

Which of the following statements best describes the role of cyclic AMP in the signal transduction pathway?

Which of the following statements best describes the role of cyclic AMP in the signal transduction pathway? It acts as a second messenger that helps relay and amplify the signal within the cell.

What is SOS in RTK?

Sos, a Guanine Nucleotide – Exchange Factor, Binds to the SH3 Domains in GRB2. In addition to one SH2 domain, which binds to phosphotyrosine residues in RTKs, GRB2 contains two SH3 domains, which bind to Sos, a guanine nucleotide – exchange factor.

Is Ras a protein?

Ras, from “Rat sarcoma virus”, is a family of related proteins that are expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction).

What does Richard Dawkins mean by the term phenotype?

Richard Dawkins described a phenotype that included all effects that a gene has on its surroundings, including other organisms, as an extended phenotype, arguing that “An animal’s behavior tends to maximize the survival of the genes ‘for’ that behavior, whether or not those genes happen to be in the body of the particular animal performing it.”

Which is the correct definition of the term phenotype?

The term “phenotype” has sometimes been incorrectly used as a shorthand for phenotypic difference from wild type, yielding the statement that a “mutation has no phenotype”. Another extension adds behavior to the phenotype, since behaviors are observable characteristics. Behavioral phenotypes include cognitive, personality, and behavioral patterns.

How did Wilhelm Johannsen come up with the phenotype?

Wilhelm Johannsen proposed the genotype-phenotype distinction in 1911 to make clear the difference between an organism’s heredity and what that heredity produces. The distinction resembles that proposed by August Weismann (1834-1914), who distinguished between germ plasm (heredity) and somatic cells (the body).

How does a phenotype affect the fitness of an organism?

The concept of phenotype can be extended to variations below the level of the gene that affect an organism’s fitness. For example, silent mutations that do not change the corresponding amino acid sequence of a gene may change the frequency of guanine-cytosine base pairs (GC content).