What does TPO Ab stand for?

Autoantibodies to thyroid peroxidase (TPOAb) are produced within the body. The presence of TPOAb in the blood reflects a prior attack on the thyroid tissue by the body’s immune system.

What should TPO levels be?

Thyroid peroxidase antibody (TPOAb): Less than 35 IU/mL. Thyroglobulin antibody (TgAb): Less than 20 IU/mL. Thyroid-stimulating immunoglobulin antibody (TSI): Less than 140% of basal activity. Thyroid-stimulating hormone (TSH) receptor binding inhibitor immunoglobulin (TBII)/TRAb: 1.75 IU/L or less.

What is a high TPO antibody level?

Values above 9.0 IU/mL generally are associated with autoimmune thyroiditis, but elevations are also seen in other autoimmune diseases.

What does TPO test for?

TPO plays an important role in the production of thyroid hormones. A TPO test detects antibodies against TPO in the blood. If you’ve been diagnosed with thyroid disease, your doctor may suggest a TPO antibody test and other thyroid tests to help find the cause.

What happens if anti-TPO is high?

The presence of TPO antibodies in your blood suggests that the cause of thyroid disease is an autoimmune disorder, such as Hashimoto’s disease or Graves’ disease. In autoimmune disorders, your immune system makes antibodies that mistakenly attack normal tissue.

Why is TPO high?

What does it mean to have positive TPO antibody?

Positive antibodies to TPO and/or Tg – this result indicate a patient may have Hashimoto’s thyroiditis The higher the level of antibodies, the more likely it is that a patient has an autoimmune disease of the thyroid e.g., Hashimoto’s or Graves’ disease.

Can a person with TPO antibodies not have thyroid disease?

Some people with TPO antibodies may not have thyroid disease. However, the presence of TPO antibodies may increase the risk of future thyroid disorders. If you have normal thyroid function with TPO antibodies, your doctor may recommend periodic checkups to watch for future thyroid problems. Chernecky CC, et al., eds. Thyroid Peroxidase Antibody.

Which is the most common autoantibodies of TPO?

The highest TPO antibody levels are observed in patients suffering from Hashimoto thyroiditis. In this disease, the prevalence of TPO antibodies is about 90% of cases, confirming the autoimmune origin of the disease. These autoantibodies also frequently occur (60%-80%) in the course of Graves disease.

How does TPO affect thyroid follicular cell function?

Decreased activity or expression of TPO impairs thyroid follicular cell function by decreasing iodide trapping and impairing synthesis of thyroid hormone. What are thyroid peroxidase antibodies?