What lab values does cyclosporine affect?

Low blood magnesium level. High blood potassium level. Liver damage (hepatotoxicity) that may cause jaundice, including yellow eyes, dark urine and/or pale stools. Diarrhea.

What happens when cyclosporine level is high?

In the case of kidney transplantation, blood levels help to distinguish between kidney rejection and kidney damage due to high levels of cyclosporine. Cyclosporine is associated with several toxic side effects that can be avoided if blood levels are monitored and the dose adjusted if the level detected is too high.

How do you monitor cyclosporine?

For cyclosporine C2 monitoring, blood should be drawn within 15 min of the 2-h postdose time point (36). For cyclosporine or tacrolimus trough-level monitoring, blood should be drawn 12 h after the last dose (i.e., immediately before the next dose).

How do you titrate cyclosporine?

-Titration: If insufficient benefit is seen at 4 weeks and tolerability is good at the initial dose, the dose may be increased by 0.5 mg/kg/day at 2-week intervals based on patient response. -Note: Doses below 2.5 mg/kg/day may also be effective.

What is the normal cyclosporine level?

Based on the monitor results, we now can define the ideal therapeutic range of cyclosporine in whole blood as follows: 500-600 ng/ml in the first week of post-transplantation, 600-800 ng/ml in the second week to sixth month of post-transplantation, 400-600 ng/ml in the seventh to twelfth month of post-transplantation …

What is a good cyclosporine level?

Most individuals display optimal response to cyclosporine with trough whole blood levels 100 to 400 ng/mL. Preferred therapeutic ranges may vary by transplant type, protocol, and comedications.

What is a normal cyclosporine level?

Is cyclosporine an antibiotic?

The intrinsic antibiotic activity of cyclosporine is limited; although it inhibits certain viruses, fungi, protozoa, and helminths, in practical terms these effects are insignificant.

Is cyclosporine safe?

However, cyclosporine is potentially toxic. Side effects include renal toxic effects, hypertension, and an increased risk of malignant neoplasm. The toxicity of cyclosporine is dose-related, yet the safe duration of treatment is undefined.

Does cyclosporine increase blood pressure?

Authors’ conclusions: Cyclosporine statistically significantly increases blood pressure compared to placebo in a dose-related fashion. The magnitude of increase in blood pressure is clinically significant and increases the risk of stroke, myocardial infarction, heart failure and other adverse cardiovascular events associated with elevated BP.

Why is cyclosporine given to transplant patients?

This is because the immune system treats the new organ as an invader. Cyclosporine is used to prevent organ rejection after a kidney, heart, or liver transplant. Cyclosporine is also used to treat severe psoriasis or severe rheumatoid arthritis.

Will you have fever with cyclosporine?

Fever is found among people who take Cyclosporine, especially for people who are male, 50-59 old , have been taking the drug for < 1 month, also take medication Prednisolone, and have Stem cell transplant.

Can cyclosporine cause high blood pressure?

Cyclosporine can also cause high blood pressure and kidney problems. The risk of both problems increases with higher doses and longer treatment with this drug. Your doctor will monitor your blood pressure and kidney function while you take this medication.